I wrote the following as a response to something else...
"I am probably both somewhat rationalistic and somewhat nihilistic. I take the general Nietzschean point about the lack of foundations for a meaningful human life to be entirely true, and to an extent one can embrace and even celebrate this as liberating, fashioning one's own meanings out of the materials one inherits, appropriates, or even invents for oneself. But then along comes the Buddha with old age, sickness, suffering and death, and none of these things strike me as particularly worth celebrating. An appreciation of one’s own mortality is one of the curses of self-consciousness; animals do not live every day knowing that they have to die, or indeed that they could do so at any moment with all their works unfinished. And that is merely at the individual level. When one surveys the extent of the vanity, stupidity, misery, and injustice in the world at large, one can indeed feel quite nihilistic about the human condition.
There was a lot to be said for the medieval conception of humanity as situated between the angels and the beasts – we are creatures of marvelous intellectual, artistic and scientific creativity, and great sympathy, friendship, and love for one another, on the one hand, and greedy, short-sighted, and even willfully destructive and malevolent, on the other. In the face of this paradox it is sometimes easy to despair, and for the insane laughter of absurdity to take over. Reason, insofar as it can recall one firmly to the facts of the matter, and thus pave the way for constructive action, is in this sense a kind of solution – but it is of course reason with a small ‘r’ that I have in mind, and it goes along with the cultivation of a ‘better half’ in oneself that cannot, in the end, rely solely on reason. Even then it offers no ultimate guarantee; there is actually no way I can see of insulating oneself altogether from nihilism, though that may in the end just be a matter of (my) temperament – some individuals may simply possess more natural equanimity (or insensitivity?) than myself (sensitivity by no means being an unqualified good; it can take a morbid form that can be quite literally unhealthy)."